Debiopharm's Debio 1124, a Molecular-targeted Radiotherapy Advances Into Clinical Research
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Debiopharm's Debio 1124, a Molecular-targeted Radiotherapy Advances Into Clinical Research

Debiopharm's Debio 1124, a Molecular-targeted Radiotherapy Advances Into Clinical Research

First patient dosed in the phase I small cell lung cancer (SCLC) trial with Debio 1124, a molecular-targeted radiotherapy

On August 26, 2020, Debiopharm, a Swiss-based, global biopharmaceutical company, announced the first patient dosed in the multicenter, single-arm, open-label Phase 1 study assessing the safety, distribution, and dosing of Debio 1124 in patients with advanced, unresectable pulmonary and extrapulmonary small cell carcinoma. This targeted, investigational radiotherapy belongs to the emerging class of Peptide Receptor Radionuclide Therapies (PRRT), having been designed to selectively deliver molecular radiotherapy to tumor cells expressing the cholecystokinin 2 receptor (CCK2R). The research will leverage a theranostic approach, combining both diagnostic and therapeutic capacities of the compound. This will allow the pre-identification of patients who have the CCK2R receptors necessary to respond to the targeted radiotherapy using an imaging dose of Debio 1124 followed by a therapeutic dose of the same compound for qualifying patients only.

The advancement of the Debio 1124 program is part of Debiopharm's expanding radio-oncology pipeline including other radiopharmaceutical and chemoradiotherapy enhancing compounds. Initially discovered by the Swiss-based Paul Scherrer Institute (PSI), before being licensed by Debiopharm, Debio 1124 has shown anti-tumor activity in pre-clinical cancer models. The advancement of Debio 1124 into this clinical study may reveal improved therapeutic results for suffering from pulmonary and extrapulmonary small cell carcinoma.

"We're very excited to bring the potential benefit of molecular radiotherapy to patients with small cell lung cancer showing expression of CCK2R. PRRT has the potential to impact the tumor while minimizing the off-target effects," explained Carlos Chanquia, Medical Director of Oncology at Debiopharm.

SCLC is a highly aggressive cancer associated with patients over 65 years old with a history of smoking. Without treatment, extensive-stage small cell lung cancer (ES-SCLC), representing approximately two-thirds of all cases, is rapidly and invariably fatal.[1] Combination chemotherapy induces dramatic but short-lived responses, with median overall survival in the third line setting <6 months. Ongoing research will evaluate if SCLC could potentially benefit from this specifically targeted radiotherapy. 

About Debio 1124 

Debio 1124 is a new-generation peptide analogue of minigastrin, coupled to the isotope Lutetium 177 (177Lu) designed to selectively deliver molecular radiotherapy to tumor cells expressing the Cholecystokinin B Receptor (CCK2R). The compound can be used as both a diagnostic tool during the initial imaging step and subsequently as an intravenous radiopharmaceutical for treatment. This targeted, theragnostic compound is being researched in various cancer types including advanced Medullary Thyroid Cancer (MTC) and SCLC. 

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